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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 1
1975 4
1977 1
1979 1
1980 3
1983 3
1984 5
1985 4
1986 3
1987 2
1988 4
1989 2
1990 3
1991 1
1992 3
1993 7
1994 2
1995 7
1996 5
1997 4
1998 7
1999 10
2000 4
2001 7
2002 5
2003 15
2004 10
2005 13
2006 12
2007 19
2008 13
2009 22
2010 23
2011 25
2012 26
2013 28
2014 28
2015 34
2016 26
2017 27
2018 36
2019 27
2020 35
2021 41
2022 40
2023 35
2024 17

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595 results

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Page 1
Brain stem control of swallowing: neuronal network and cellular mechanisms.
Jean A. Jean A. Physiol Rev. 2001 Apr;81(2):929-69. doi: 10.1152/physrev.2001.81.2.929. Physiol Rev. 2001. PMID: 11274347 Free article. Review.
Interestingly, these generator neurons are situated within a primary sensory relay, that is, the nucleus tractus solitarii. The second group is located in the ventrolateral medulla and contains switching neurons, which distribute the swallowing drive to the various …
Interestingly, these generator neurons are situated within a primary sensory relay, that is, the nucleus tractus solitarii. The secon …
Predicting multiple conformations via sequence clustering and AlphaFold2.
Wayment-Steele HK, Ojoawo A, Otten R, Apitz JM, Pitsawong W, Hömberger M, Ovchinnikov S, Colwell L, Kern D. Wayment-Steele HK, et al. Nature. 2024 Jan;625(7996):832-839. doi: 10.1038/s41586-023-06832-9. Epub 2023 Nov 13. Nature. 2024. PMID: 37956700 Free PMC article.
To test AF-Cluster's sensitivity to point mutations, we designed and experimentally verified a set of three mutations predicted to flip KaiB from Rhodobacter sphaeroides from the ground to the fold-switched state. Finally, screening for alternative states in protein famili …
To test AF-Cluster's sensitivity to point mutations, we designed and experimentally verified a set of three mutations predicted to flip KaiB …
Fluid Ferroelectric Filaments.
Máthé MT, Perera K, Buka Á, Salamon P, Jákli A. Máthé MT, et al. Adv Sci (Weinh). 2024 Mar;11(9):e2305950. doi: 10.1002/advs.202305950. Epub 2023 Dec 21. Adv Sci (Weinh). 2024. PMID: 38126584 Free PMC article.
Ferroelectric nematic fluid threads may have practical applications in nano-fluidic micron-size logic devices, switches, and relays....
Ferroelectric nematic fluid threads may have practical applications in nano-fluidic micron-size logic devices, switches, and relay
Redox-mediated structural and functional switching of C-repeat binding factors enhances plant cold tolerance.
Wi SD, Lee ES, Park JH, Chae HB, Paeng SK, Bae SB, Phan TKA, Kim WY, Yun DJ, Lee SY. Wi SD, et al. New Phytol. 2022 Feb;233(3):1067-1073. doi: 10.1111/nph.17745. Epub 2021 Oct 18. New Phytol. 2022. PMID: 34537981 Free article. Review.
However, upon translocation to the nucleus under a cold snap, the h2-isotype of cytosolic thioredoxin (Trx-h2), reduces the oxidized (inactive) CBF oligomers and the newly synthesized CBF monomers, thus producing reduced (active) CBF monomers. Thus, the redox-dependent structural …
However, upon translocation to the nucleus under a cold snap, the h2-isotype of cytosolic thioredoxin (Trx-h2), reduces the oxidized (inacti …
The heart is lost without the hypothalamus.
Pyner S. Pyner S. Handb Clin Neurol. 2021;182:355-367. doi: 10.1016/B978-0-12-819973-2.00024-1. Handb Clin Neurol. 2021. PMID: 34266605 Review.
The preautonomic neurons of the PVN adjust their level of activation in response to afferent signals arising from peripheral viscerosensory receptors relayed through the nucleus tractus solitarius. The prevailing sympathetic tone is a balance between excitatory and inhibit …
The preautonomic neurons of the PVN adjust their level of activation in response to afferent signals arising from peripheral viscerosensory …
Toward an Integrative Theory of Thalamic Function.
Rikhye RV, Wimmer RD, Halassa MM. Rikhye RV, et al. Annu Rev Neurosci. 2018 Jul 8;41:163-183. doi: 10.1146/annurev-neuro-080317-062144. Epub 2018 Apr 4. Annu Rev Neurosci. 2018. PMID: 29618284 Review.
According to this view, the thalamus is an excitatory feedforward relay to or between cortical regions, and cognitively relevant computations are exclusively cortical. ...Considering their architectural features as well as their ability to initiate, sustain, and switch
According to this view, the thalamus is an excitatory feedforward relay to or between cortical regions, and cognitively relevant comp …
The amygdala, a relay station for switching on and off pain.
Rouwette T, Vanelderen P, Roubos EW, Kozicz T, Vissers K. Rouwette T, et al. Eur J Pain. 2012 Jul;16(6):782-92. doi: 10.1002/j.1532-2149.2011.00071.x. Epub 2011 Dec 19. Eur J Pain. 2012. PMID: 22337528 Review.
On the basis of the reviewed literature, we postulate a central mechanism for pain control in which the amygdala plays a critical role by switching on and off chronic pain. In this mechanism, upon pain stimuli, CRFR1 in the amygdala is activated by CRF to induce hyperalges …
On the basis of the reviewed literature, we postulate a central mechanism for pain control in which the amygdala plays a critical role by …
Quantitative biology of hydrogen peroxide signaling.
Antunes F, Brito PM. Antunes F, et al. Redox Biol. 2017 Oct;13:1-7. doi: 10.1016/j.redox.2017.04.039. Epub 2017 May 8. Redox Biol. 2017. PMID: 28528123 Free PMC article. Review.
Thus, a redox switch with low H(2)O(2)-dependent oxidability and slow reduction rate responds to the same range of H(2)O(2) concentrations as a redox switch with high H(2)O(2)-dependent oxidability, but that is rapidly reduced. ...In spite of being a very simple mol …
Thus, a redox switch with low H(2)O(2)-dependent oxidability and slow reduction rate responds to the same range of H(2)O(2) concentra …
Tyrosine phosphorylation switching of a G protein.
Li B, Tunc-Ozdemir M, Urano D, Jia H, Werth EG, Mowrey DD, Hicks LM, Dokholyan NV, Torres MP, Jones AM. Li B, et al. J Biol Chem. 2018 Mar 30;293(13):4752-4766. doi: 10.1074/jbc.RA117.000163. Epub 2018 Jan 30. J Biol Chem. 2018. PMID: 29382719 Free PMC article.
Heterotrimeric G protein complexes are molecular switches relaying extracellular signals sensed by G protein-coupled receptors (GPCRs) to downstream targets in the cytoplasm, which effect cellular responses. ...
Heterotrimeric G protein complexes are molecular switches relaying extracellular signals sensed by G protein-coupled receptors …
PI3K signaling through a biochemical systems lens.
Madsen RR, Toker A. Madsen RR, et al. J Biol Chem. 2023 Oct;299(10):105224. doi: 10.1016/j.jbc.2023.105224. Epub 2023 Sep 9. J Biol Chem. 2023. PMID: 37673340 Free PMC article. Review.
Following 3 decades of extensive research into PI3K signaling, it is now evidently clear that the underlying network does not equate to a simple ON/OFF switch. This is best illustrated by the multifaceted nature of the many diseases associated with aberrant PI3K signaling, …
Following 3 decades of extensive research into PI3K signaling, it is now evidently clear that the underlying network does not equate to a si …
595 results